Summer Intern/Sterile Drug Product Development

Department Description:

Drug Product Development-Steriles (DPD-Steriles), part of Medicine Development Supply (MDS), is a core R&D function that supports our Research Units in the design and development of new drug products encompassing both small and biopharmaceutical molecules. We bring together outstanding people across disciplines including formulation, packaging, biopharmaceutics, engineering, modelling, and process analytics to develop innovative, robust, and patient-centric medicines for sterile drug products from pre-clinical through the different phases of clinical development and commercialization. DPD-Steriles is accountable for the design, development and industrialization of drug products and their manufacturing processes.  This position is located at the Upper Providence site.

Job Description:

The Sterile Formulation Development Intern will be part of a team developing fundamental understanding of stabilization mechanisms for injectable formulations, with a particular emphasis on suspensions. 

Key learnings include:

• Apply knowledge in colloidal science, leveraging expertise in pharmaceutical sciences, chemical engineering, and material science to understand the stabilization mechanism and therefore design robust suspension drug products.
• Developing analytical methods to understand the molecular interaction and packing between various excipients and API, to understand the impact on critical quality parameters of drug products.​
• Determine important factors impacting the stability, manufacturability and performance of one or more of our sterile injectable drug delivery platforms such micro and nano-suspensions.
• Work closely with the material science team members to develop methods for material characterization.
• Create a model and/or design space for a robust drug product by analyzing the data using statistical tools. ​
• Summarize key findings via periodic meetings, presentations, and draft reports.
• At the end of the internship, you may have an opportunity to present the findings and conclusions to the department.
• Comply with GMP requirements for recording experiments and data, and writing reports, including scientific review and data checking.
• Comply with the requirements of Quality, Safety, and GSK policies and procedures to ensure that GSK intellectual property is protected.

Minimum Qualifications:

• Pursuing a graduate degree in Pharmaceutical Sciences, Chemical Engineering, Materials Science, Chemistry or related field.
• Knowledge of formulation science, material characterization and physical chemistry.
• Must be able to work full-time (35-40 hours/week) throughout the 12-week internship (May- July/August 2024).
• Must have an active student status and/or within 12 months post-graduation from a BS or MS degree program. Post-doctoral candidates are not eligible.

Preferred Qualifications:

• Basic understanding of injectable pharmaceutical formulations and manufacturing processes such as wet-bead media milling etc.
• Basic experience with techniques for studying molecular adsorption and adsorption modelling.
• Hands on experience working on micro- or nanoparticle formulations development.
• Knowledge of Design of Experiment, multivariate analysis.
• Calorimetric techniques and particle size measurement

Benefits:

• While GSK embraces a flexible work environment, we do require certain positions to be onsite. Candidates who are hired for an on-site role or hybrid role, and reside outside of 50-miles from their assigned work location, are eligible for relocation stipend. This is a one-time payment to help offset housing & relocation expenses. Please refer to the position details for the requirements of each position.
• GSK Interns and Co-ops are offered a competitive hourly pay rate and benefits. Please note, benefits eligibility determined the month following date of hire.

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Eligibility Requirements:

Must successfully pass a drug screen and background check prior to assignment target start date.  

• If your skillsets are a match for this role, you will be contacted by our recruitment team with next steps to complete our internal World of GSK Assessment.
  • Please note, you must receive a passing score to move forward in the interview process. Once your assessment is complete, a recruiter will review your results and be in touch with next steps.