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Fall Co-op/DMPK Discovery

Department Description
The GlaxoSmithKline U.S. Drug Metabolism and Pharmacokinetics (DMPK) organization is responsible for the delivery of key DMPK support (in vitro, pharmacokinetic, and bioanalytical) that helps drive early drug discovery programs. Within that structure, the Bioanalytical team is responsible for the quantitation of drug and drug related molecules in samples generated both in vitro and in vivo.

Additionally, a key remit of the U.S. DMPK organization is the modernization and optimization of processes to allow for increased throughput and efficiency. A pivotal aspect of that remit is the expansion of DMPK screening assays within GSK utilizing new bioanalytical approaches. The support of these assays presents an opportunity for a student to learn and contribute via sample preparation, LC-MS/MS and SPE-MS/MS analysis, and data interpretation and tracking.

Job Description
The GlaxoSmithKline U.S. Drug Metabolism and Pharmacokinetics group is seeking a highly motivated individual to join our bioanalytical team.The student’s primary responsibility will be assisting in the analysis of DMPK screening assays using both LC-MS/MS and high throughput SPE-MS/MS platforms. Through working closely with bioanalytical team members, our co-op will learn key concepts of mass spectrometry analyses, including sample preparation, instrument/data analysis software, and data interpretation. Additionally, a co-op may have opportunities to evaluate related analytical methodologies in an effort to optimize workflows. The ability to work both independently and within a team environment is expected.

Specifically, our co-op can expect to learn, contribute through, and come away with a tangible skill set including:
• An understanding and application of relative quantitation via LC-MS/MS and SPE-MS/MS
• Analyzing, interpreting, and presenting data to DMPK staff
• Helping with the implementation and assessment of new methodologies for sample analysis
• Assisting in troubleshooting and optimizing workflows based on experiences during instrument use and data analysis

Minimum Qualifications
  • Pursuing a Bachelor's, Master's, or PhD in Chemistry or Biology, or similar disciplines.
  • Must be able to work full-time (35-40 hours/week) throughout the 6 month co-op.
  • Must have an active student status and/or within 12 months post-graduation from a BS or MS degree program. Post-doctoral candidates are not eligible.

Preferred Qualifications
  • Experience with mass spectrometry.
  • Experience with liquid chromatography.
  • Experience with pipetting.

  • While GSK embraces a flexible work environment, we do require certain positions to be onsite. Candidates who are hired for an on-site role and reside outside of 50-miles from their assigned work location are eligible for relocation stipend. This is a one-time payment to help offset housing & relocation expenses. Please refer to the position details for the requirements of each position.
  • GSK Interns and Co-ops are offered a competitive hourly pay rate and benefits. Please note, benefits eligibility determined the month following date of hire.

Eligibility Requirements
  • Must successfully pass a drug screen and background check prior to assignment target start date.
  • If your skillsets are a match for this role, you will be contacted by our recruitment team with next steps to complete our internal World of GSK Assessment.
  • Please note, you must receive a passing score to move forward in the interview process. Once your assessment is complete, a recruiter will review your results and be in touch with next steps.