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Co-op, Chemical Biology & Proteomics

About Biogen: 
 
At Biogen, our mission is clear - we are pioneers in neuroscience. Biogen discovers, develops, and delivers worldwide innovative therapies for people living with serious neurological and neurodegenerative diseases. Together, our employees create, commercialize, and manufacture transformative therapies for our patient population.  
 
We at Biogen are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients who we serve. We are focused on strengthening our foundation to advance our overall Diversity, Equity and Inclusion (DE&I) strategy and, most importantly, ensure all our employees feel included. 
 
As an intern or co-op at Biogen, you can expect to be placed on a real project, under the guidance of experience professionals and subject matter experts who are invested in your career and academic growth. We also ensure that you have plenty of opportunities to build your network, learn more about our organization through weekly lunch and learns led by leaders from across the company, and join us for several fun events.  
 
Summary 
 
This application is for a 6-month student role from July - December 2023. Resume review begins in January 2023. 
 
The Chemical Biology and Proteomics (CBP) group works on a wide range of research projects that support the Biogen pipeline by designing and executing robust and reproducible bioanalytical assays. CBP capabilities include but are not limited to higher-resolution interrogation of novel biology and the molecular mechanism of action of molecules that help advance the best drug candidates into the clinic. 
 
Position Description 
 
Biogen is searching for a highly motivated and collaborative Summer Co-op to join the Chemical Biology and Proteomics (CBP) group within the Biotherapeutics and Medicinal Sciences department (BTMS). Our group develops and applies advanced proteomics methods in supporting therapeutics characterization (target engagement, lead compound selectivity and drug MOA, etc.), target biology and validation, and advancement of drug discovery tools. Technology development is an essential and fundamental component of the group function to support the Biogen portfolio. The Co-op will adapt their chemical biology and mass spectrometry techniques skills to answer biomedically focused research questions in cutting-edge laboratories for drug discovery.  
 
A prospective candidate will perform the following tasks including but not limited to: 
 
  • Characterize and evaluate of chemical probes in biological systems for target identification, target engagement and selectivity profiling  
  • Combine the application of chemical biology methods and proteomics techniques for cellular protein activity profiling and mechanism of action (MOA) study 
  • Proteomics sample preparation, proteomics data processing and bioinformatics analysis. 
  • Operation and instrumentation of modern LC-MS systems 
  • Work with mentoring scientists on method development and troubleshooting  
  • Maintain good written records of laboratory procedures, attend group/team meetings and present at an internal session at the end of the program 
  • Engage and interact with scientists within and outside the team 
 
 
Qualifications 
 
  • Good communication and inter-personal skills 
  • Familiarity with basic chemical biology concepts and techniques, such as click-chemistry, activity-based protein profiling, photochemical crosslinking and chemoproteomics. 
  • Experience in the following skills: 
  • Basic laboratory techniques, including pipetting, protein quantification, cell lysis, click chemistry, gel electrophoresis, and Western blotting.  
  • Mammalian cell/tissue culture expertise, including practical experience with transfection (stable/transient overexpression and knockdown by lentiviral transduction and plasmid transfection). 
  • Affinity enrichment or immunoprecipitation workflows from mammalian cell lysate. 
  • Familiarity or previous expertise with mass spectrometry, LC-MS/MS, and quantitative proteomics.  
  • Perform data analysis and visualization using appropriate software 
  • Efficiently manage time to enable pursuit of multiple objectives in parallel 
 
To participate in the Biogen Co-op Program, students must meet the following eligibility criteria: 
  • Legal authorization to work in the U.S. 
  • At least 18 years of age prior to the scheduled start date 
  • Be currently enrolled in an accredited college or university 
 
Education 
 
Currently enrolled in a Master’s or Ph.D. program in chemical biology, chemistry, biochemistry, or a related discipline. 
 
Location 
 
Cambridge, MA