Quantum Dynamics of Mitochondria Doctoral/Postdoctoral Internship
As an ORISE participant, you will join a community of scientists and researchers in an effort to gain knowledge in areas related to the Air Force Research Laboratory's (AFRL) mission.
In view of the importance of mitochondria, this project addresses fundamental questions regarding the understanding of the quantum dynamics of electron transfer in mitochondria and their regulation by photoactivated Nanomaterials (NMs). Mitochondrial health is a critical indicator of medical attributes and is capable of measuring an individual’s physiological condition. Human health, performance, and endurance are dependent upon the health of the cell’s mitochondria. The exposure to operational stress factors is linked to critical medical attributes that impact Airmen performance. During intense exercise or physical activity, the body’s consumption of ATP rises, but the electron transport chain (ETC) and ATP synthase can not keep up with the increasing demand for ATP, leading to premature fatigue.
Stress induced oxidative stress is known to decrease mitochondrial activity by depleting ATP levels, photobiomodulation (PBM) has been studied as a potential prevention, where the cell absorbs light to increase ATP production. However, the practical application of PBM is controversial and photothermal effect can be detrimental to the cell. Therefore it is important to control and understand the dynamics of electron transfer and the proton gradient to enhance ATP production. One example- NMs can be programed to couple to the ETC through attaching a bio-molecule that binds to a protein in the ETC and regulate ATP production. By designing the NM’s optical properties such that it acts as an electron donor, the NM can be excited with light and transfer an electron into the ETC. By pumping electrons into the ETC in this manner, the electron transport rate should increase, increasing the proton gradient and therefore production of ATP to delay the onset of fatigue and injury induced trauma.
Why should I apply?
You will develop and advance your professional and academic career through doctoral and/or post-doctoral training. This exciting opportunity not only provides advanced research training during and beyond the doctoral degree but prepares you to follow scientific careers at the AFRL. Along the way, you will engage in activities and research in several areas. These include, but are not limited to, conducting research on the following objectives:
- Designing and programing biologically-conjugated advanced materials NMs that can increase the rate of electron transfer and ATP production in mitochondria to combat stress induced premature fatigue and enhance airmen readiness.
- Regulating the electron transfer rate by photoexciting NMs that can donate electrons into the ETC thereby modulate production of ATP in mitochondria.
- Characterizing and quantifying the intracellular source of photon emission, identify cellular biomolecules (proteins, receptors, etc.) involved in wave-mediated signaling, and characterize changes caused by biophoton signaling.
Where will I be located?
Wright State University in Dayton, Ohio
What is the anticipated start date?
Exact start dates will be determined at the time of selection and in coordination with the selected candidate. Applications are reviewed on an ongoing basis and internships will be filled as qualified candidates are identified.
What is the appointment length?
An ORISE appointment period can be a short-term (less than 2 weeks), summer (10-12 weeks), or yearlong appointment. Appointments may be extended depending on funding availability, project assignment, program rules, and availability of the participant.
What are the benefits?
You will receive a stipend to be determined by AFRL. Stipends are typically based on a participant’s academic standing, discipline, experience, and research facility location. Other benefits may include the following:
- Health Insurance Supplement (Participants are eligible to purchase health insurance through ORISE)
- Relocation Allowance
- Training and Travel Allowance
AFRL leads the discovery, development and integration of affordable warfighting technologies for America's air, space and cyberspace forces. AFRL is a full-spectrum laboratory, responsible for planning and executing the Air Force's science and technology program. AFRL leads a worldwide government, industry and academic partnership in the discovery, development and delivery of a wide range of revolutionary technologies. The laboratory provides leading edge warfighting capabilities keeping our air, space and cyberspace forces the world's best. The 711 Human Performance Wing advances human performance in air, space and cyberspace through research, education and consultation, accomplished through the synergies created by the wing’s two distinct but complementary entities: Airman Systems Directorate and U.S. Air Force School of Aerospace Medicine. For more information about AFRL, visit https://www.wpafb.af.mil/afrl/.
This program, administered by Oak Ridge Associated Universities (ORAU) through its contract with the U.S. Department of Energy (DOE) to manage the Oak Ridge Institute for Science and Education (ORISE), was established through an interagency agreement between DOE and DoD. Participants do not enter into an employee/employer relationship with ORISE, ORAU, DoD or any other office or agency. Instead, you will be affiliated with ORISE for the administration of the appointment through the ORISE appointment letter and Terms of Appointment. Proof of health insurance is required for participation in this program. Health insurance can be obtained through ORISE. For more information, visit the ORISE Research Participation Program at the U.S. Department of Defense.
The qualified candidate should currently be pursuing or recently have received a doctoral degree. Degree must have been received within five years of the appointment start date.
Highly competitive postdoctoral applicants will have education and/or experience in one or more of the following:
- Demonstrable record of high-impact, peer-reviewed publications on biophotonics, mitochondria, or related disciplines.
- Well-developed planning and organizational skills, with the ability to prioritize multiple tasks and set and meet deadlines.
- Excellent written communication and verbal communication skills with proven ability to produce clear, succinct reports.
- Characterization and quantification of intracellular source of photon emission, identification of cellular biomolecules (proteins, receptors, etc.) involved in wave-mediated signaling, and characterization changes caused by biophoton signaling.
- Experience in mitochondria isolation, studies quantum properties, electron microscopy, confocal microscopy.
- Ability to work highly independently and interpret analytical data.
- An excellent team player with great initiative and demonstrated capacity to work in a collegiate manner.
- Citizenship: U.S. Citizen Only
- Degree: Doctoral Degree received within the last 60 months or currently pursuing